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ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC
CD44, an extracellular matrix (ECM) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCC orasphere formation or stemness was characterized by cleavage of CD44, and thus we hypothesized that this proteolytic proc...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Publishing Ltd
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3892384/ https://ncbi.nlm.nih.gov/pubmed/24403253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.147 |
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