ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC

CD44, an extracellular matrix (ECM) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCC orasphere formation or stemness was characterized by cleavage of CD44, and thus we hypothesized that this proteolytic proc...

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Bibliographic Details
Main Authors: Kamarajan, Pachiyappan, Shin, Jae M, Qian, Xu, Matte, Bibiana, Zhu, Joey Yizhou, Kapila, Yvonne L
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892384/
https://ncbi.nlm.nih.gov/pubmed/24403253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.147
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