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Fully Reagent-Controlled Asymmetric Synthesis of (−)-Spongidepsin via the Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA Reaction)

[Image: see text] The ZACA reaction has been shown to proceed satisfactorily with internally OH-substituted 1-alkenes, provided that the OH group is unprotected and non-allylic. This reaction was used for reagent-controlled asymmetric construction of 3. Allylic alcohol was converted to 2 in 7 steps...

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Autors principals: Zhu, Gangguo, Negishi, Ei-ichi
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891660/
https://ncbi.nlm.nih.gov/pubmed/17583343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0707259
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