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JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891630/ https://ncbi.nlm.nih.gov/pubmed/24470973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/jkst.24635 |
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