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ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD pathology remains unclear. In vivo, dendritic spine density is...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Neurochemistry
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891498/ https://ncbi.nlm.nih.gov/pubmed/24328732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20130043 |
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