Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium

BACKGROUND: Palmitic acid(16:0), stearic acid(18:0), palmitoleic acid(16:1n-7), and oleic acid(18:1n-9) are major saturated and mono-unsaturated fatty acids that affect cellular signaling and metabolic pathways. They are synthesized via de novo lipogenesis (DNL) and are the main saturated and mono-u...

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Main Authors: Wu, Jason H.Y., Lemaitre, Rozenn N., Manichaikul, Ani, Guan, Weihua, Tanaka, Toshiko, Foy, Millennia, Kabagambe, Edmond K., Djousse, Luc, Siscovick, David, Fretts, Amanda M., Johnson, Catherine, King, Irena B., Psaty, Bruce M., McKnight, Barbara, Rich, Stephen S., Chen, Yii-Der I., Nettleton, Jennifer A., Tang, Weihong, Bandinelli, Stefania, Jacobs, David R., Browning, Brian L., Laurie, Cathy C., Gu, Xiangjun, Tsai, Michael Y., Steffen, Lyn M., Ferrucci, Luigi, Fornage, Myriam, Mozaffarian, Dariush
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891054/
https://ncbi.nlm.nih.gov/pubmed/23362303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.112.964619
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