NCOA5 Haplo-insufficiency Results in Glucose Intolerance and Subsequent Hepatocellular Carcinoma

Type 2 Diabetes (T2D) and male gender are associated with hepatocellular carcinoma (HCC) development. We demonstrate that heterozygous deletion of the Ncoa5 gene causes spontaneous development of HCC, exclusively in male mice. Tumor development is preceded by increased IL-6 expression, early-onset g...

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Detalhes bibliográficos
Main Authors: Gao, Shenglan, Li, Aimin, Liu, Feiye, Chen, Fengsheng, Williams, Mark, Zhang, Chengliang, Kelley, Zakiya, Wu, Chin-Lee, Luo, Rongcheng, Xiao, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891053/
https://ncbi.nlm.nih.gov/pubmed/24332041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.11.005
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