Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome

Aneuploidy has been recognized as a hallmark of cancer for over 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here we develop Tumor Suppressor and Oncogene (TUSON) Explorer, a computational method that analyzes the patterns of mutational sign...

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Bibliografiske detaljer
Main Authors: Davoli, Teresa, Xu, Andrew Wei, Mengwasser, Kristen E., Sack, Laura M., Yoon, John C., Park, Peter J., Elledge, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891052/
https://ncbi.nlm.nih.gov/pubmed/24183448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.10.011
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