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Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines

The rapid dissemination of the 2009 pandemic H1N1 influenza virus emphasizes the need for universal influenza vaccines that would broadly protect against multiple mutated strains. Recent efforts have focused on the highly conserved hemagglutinin (HA) stem domain, which must undergo a significant con...

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Autori principali: Lu, Yuan, Welsh, John P., Swartz, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890838/
https://ncbi.nlm.nih.gov/pubmed/24344259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308701110
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