Epstein–Barr Virus Nuclear Antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A

Epstein–Barr virus nuclear antigen 3C (EBNA3C) repression of CDKN2A p14(ARF) and p16(INK4A) is essential for immortal human B-lymphoblastoid cell line (LCL) growth. EBNA3C ChIP-sequencing identified >13,000 EBNA3C sites in LCL DNA. Most EBNA3C sites were associated with active transcription; 64%...

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Bibliografiska uppgifter
Huvudupphovsmän: Jiang, Sizun, Willox, Bradford, Zhou, Hufeng, Holthaus, Amy M., Wang, Anqi, Shi, Tommy T., Maruo, Seiji, Kharchenko, Peter V., Johannsen, Eric C., Kieff, Elliott, Zhao, Bo
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890834/
https://ncbi.nlm.nih.gov/pubmed/24344258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321704111
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