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Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16(INK4A) and p14(ARF) expression

Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) and EBNA3A are each essential for EBV conversion of primary human B lymphocytes into continuously proliferating lymphoblast cell lines (LCLs) and for maintaining LCL growth. We now find that EBNA3C and EBNA3A's essential roles are to repress...

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Detalhes bibliográficos
Main Authors: Maruo, Seiji, Zhao, Bo, Johannsen, Eric, Kieff, Elliott, Zou, James, Takada, Kenzo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033265/
https://ncbi.nlm.nih.gov/pubmed/21245331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019599108
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