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Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity
The self-reactivity of their T-cell antigen receptor (TCR) is thought to contribute to the development of immune regulatory cells, such as invariant NK T cells (iNKT). In the mouse, iNKT cells express TCRs composed of a unique Vα14-Jα18 rearrangement and recognize lipid antigens presented by CD1d mo...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890789/ https://ncbi.nlm.nih.gov/pubmed/24344267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320777110 |
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