Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that shape CD1 diversity remain unclear. In mice, two...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Sundararaj, Srinivasan, Zhang, Jingjing, Krovi, S. Harsha, Bedel, Romain, Tuttle, Kathryn D., Veerapen, Natacha, Besra, Gurdyal S., Khandokar, Yogesh, Praveena, T., Le Nours, Jérôme, Matsuda, Jennifer L., Rossjohn, Jamie, Gapin, Laurent
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
Onderwerpen:
PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819427/
https://ncbi.nlm.nih.gov/pubmed/29351991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716669115
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