Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

The self-reactivity of their T-cell antigen receptor (TCR) is thought to contribute to the development of immune regulatory cells, such as invariant NK T cells (iNKT). In the mouse, iNKT cells express TCRs composed of a unique Vα14-Jα18 rearrangement and recognize lipid antigens presented by CD1d mo...

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Main Authors: Bedel, Romain, Berry, Richard, Mallevaey, Thierry, Matsuda, Jennifer L., Zhang, Jingjing, Godfrey, Dale I., Rossjohn, Jamie, Kappler, John W., Marrack, Philippa, Gapin, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890789/
https://ncbi.nlm.nih.gov/pubmed/24344267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320777110
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