Targeting Bcl-2/Bcl-X(L) Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts

PURPOSE: Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequentl...

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Main Authors: Némati, Fariba, de Montrion, Catherine, Lang, Guillaume, Kraus-Berthier, Laurence, Carita, Guillaume, Sastre-Garau, Xavier, Berniard, Aurélie, Vallerand, David, Geneste, Olivier, de Plater, Ludmilla, Pierré, Alain, Lockhart, Brian, Desjardins, Laurence, Piperno-Neumann, Sophie, Depil, Stéphane, Decaudin, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890263/
https://ncbi.nlm.nih.gov/pubmed/24454684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080836
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