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Practical workflow for cryo focused-ion-beam milling of tissues and cells for cryo-TEM tomography

Vitreous freezing offers a way to study cells and tissue in a near-native state by cryo-transmission electron microscopy (cryo-TEM), which is important when structural information at the macromolecular level is required. Many cells -- especially those in tissue -- are too thick to study intact in th...

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Detalhes bibliográficos
Main Authors: Hsieh, Chyongere, Schmelzer, Thomas, Kishchenko, Gregory, Wagenknecht, Terence, Marko, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890102/
https://ncbi.nlm.nih.gov/pubmed/24211822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2013.10.019
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