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Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity

TRPA1, one of the transient receptor potential channels, has been reported to be involved in nociception and inflammatory pain, suggesting that this molecule could be a promising target for the development of analgesic agents. We screened several monoterpene analogs of camphor, which is known to inh...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Takaishi, Masayuki, Uchida, Kunitoshi, Fujita, Fumitaka, Tominaga, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Japan 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889502/
https://ncbi.nlm.nih.gov/pubmed/24122170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12576-013-0289-0
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