Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice

Biodegradable poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) encapsulating triplex-forming peptide nucleic acids (PNAs) and donor DNAs for recombination-mediated editing of the CCR5 gene were synthesized for delivery into human peripheral blood mononuclear cells (PBMCs). NPs containing th...

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Detalhes bibliográficos
Main Authors: Schleifman, Erica B, McNeer, Nicole Ali, Jackson, Andrew, Yamtich, Jennifer, Brehm, Michael A, Shultz, Leonard D, Greiner, Dale L, Kumar, Priti, Saltzman, W Mark, Glazer, Peter M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889188/
https://ncbi.nlm.nih.gov/pubmed/24253260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.59
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