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Nanoparticles Deliver Triplex-forming PNAs for Site-specific Genomic Recombination in CD34(+) Human Hematopoietic Progenitors
Triplex-forming peptide nucleic acids (PNAs) are powerful gene therapy agents that can enhance recombination of short donor DNAs with genomic DNA, leading to targeted and specific correction of disease-causing genetic mutations. Therapeutic use of PNAs is severely limited, however, by challenges in...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017438/ https://ncbi.nlm.nih.gov/pubmed/20859257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.200 |
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