Protective Effects of Polyamine Depletion in Mouse Models of Type 1 Diabetes: Implications for Therapy

The underlying pathophysiology of type 1 diabetes involves autoimmune-mediated islet inflammation, leading to dysfunction and death of insulin-secreting islet β cells. Recent studies have shown that polyamines, which are essential for mRNA translation, cellular replication, and the formation of the...

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Bibliographic Details
Main Authors: Tersey, Sarah A., Colvin, Stephanie C., Maier, Bernhard, Mirmira, Raghavendra G.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888834/
https://ncbi.nlm.nih.gov/pubmed/23846959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-013-1560-7
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