IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways

The aim of this study was to investigate the anti-inflammatory effect of IL-21 on LPS-induced mouse peritoneal macrophages. The results showed that IL-21 significantly inhibited LPS-induced mRNA expression of IL-1β, TNF-α, and IL-6 in macrophages, but not of IFN-γ, IL-10, CCL5, or CXCL2. ELISA analy...

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Detalhes bibliográficos
Main Authors: Li, Su-nan, Wang, Wei, Fu, Shou-peng, Wang, Jian-fa, Liu, Hong-mei, Xie, Shan-shan, Liu, Bing-run, Li, Yang, Lv, Qing-kang, Li, Zhi-qiang, Xue, Wen-jing, Huang, Bing-xu, Chen, Wei, Liu, Ju-xiong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888770/
https://ncbi.nlm.nih.gov/pubmed/24574581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/548073
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