A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.

Compared to the wild-type parental line of S49 mouse lymphoma cells, intact cells of a mutant line (kin.A) are 10-fold less sensititive to biologic effects of exogenous cyclic adenosine 3':5'-monophophosphate (cAMP), such as induction of cAMP phosphodiesterase, cell cycle-specific growth inhibition,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hochman, J, Insel, P A, Bourne, H R, Coffino, P, Tomkins, G M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1975
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/174091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.12.5051
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