Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin

A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted. It was found that C (max), T (1/2), and AUC o...

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Autores principales: Khvostov, Mikhail V., Chernonosov, Alexander A., Tolstikova, Tatjana G., Kasakin, Marat F., Fedorova, Olga S., Dushkin, Alexander V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888672/
https://ncbi.nlm.nih.gov/pubmed/24455672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/156381
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