Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry

An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na(2)GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na(2)GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scan...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Zhang, Qihong, Polyakov, Nikolay E., Chistyachenko, Yulia S., Khvostov, Mikhail V., Frolova, Tatjana S., Tolstikova, Tatjana G., Dushkin, Alexandr V., Su, Weike
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058497/
https://ncbi.nlm.nih.gov/pubmed/29302995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1422298
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