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In Vivo Electroporation of Constitutively Expressed HIF-1α Plasmid DNA Improves Neovascularization in a Mouse Model of Limb Ischemia
OBJECTIVES: Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that stimulates angiogenesis during tissue ischemia. In vivo electroporation (EP) enhances tissue DNA transfection. We hypothesized that in vivo EP of plasmid DNA encoding a constitutively expressed HIF-1α gene enhances...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3888486/ https://ncbi.nlm.nih.gov/pubmed/23850058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2013.04.043 |
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