Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization

Reactive oxygen species (ROS) are increased in ischemic tissues and necessary for revascularization; however, the mechanism remains unclear. Exposure of cysteine residues to ROS in the presence of glutathione (GSH) generates GSH-protein adducts that are specifically reversed by the cytosolic thioltr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Watanabe, Yosuke, Murdoch, Colin E., Sano, Soichi, Ido, Yasuo, Bachschmid, Markus M., Cohen, Richard A., Matsui, Reiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889374/
https://ncbi.nlm.nih.gov/pubmed/27162359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524198113
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