BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis

Acute heat shock can induce apoptosis through a canonical pathway involving the upstream activation of caspase-2, followed by BID cleavage and stimulation of the intrinsic pathway. Herein, we report that the BH3-only protein BIM, rather than BID, is essential to heat shock-induced cell death. We obs...

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Autori principali: Mahajan, Indra M., Chen, Miao-Der, Muro, Israel, Robertson, John D., Wright, Casey W., Bratton, Shawn B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888412/
https://ncbi.nlm.nih.gov/pubmed/24427286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084388
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