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Rescue of Deleterious Mutations by the Compensatory Y30F Mutation in Ketosteroid Isomerase
Proteins have evolved to compensate for detrimental mutations. However, compensatory mechanisms for protein defects are not well understood. Using ketosteroid isomerase (KSI), we investigated how second-site mutations could recover defective mutant function and stability. Previous results revealed t...
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| Главные авторы: | , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Korea Society for Molecular and Cellular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887930/ https://ncbi.nlm.nih.gov/pubmed/23740430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-013-0013-1 |
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