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Rescue of Deleterious Mutations by the Compensatory Y30F Mutation in Ketosteroid Isomerase

Proteins have evolved to compensate for detrimental mutations. However, compensatory mechanisms for protein defects are not well understood. Using ketosteroid isomerase (KSI), we investigated how second-site mutations could recover defective mutant function and stability. Previous results revealed t...

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Bibliografiske detaljer
Main Authors: Cha, Hyung Jin, Jang, Do Soo, Kim, Yeon-Gil, Hong, Bee Hak, Woo, Jae-Sung, Kim, Kyong-Tai, Choi, Kwan Yong
Format: Artigo
Sprog:Inglês
Udgivet: Korea Society for Molecular and Cellular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887930/
https://ncbi.nlm.nih.gov/pubmed/23740430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-013-0013-1
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