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Rescue of Deleterious Mutations by the Compensatory Y30F Mutation in Ketosteroid Isomerase

Proteins have evolved to compensate for detrimental mutations. However, compensatory mechanisms for protein defects are not well understood. Using ketosteroid isomerase (KSI), we investigated how second-site mutations could recover defective mutant function and stability. Previous results revealed t...

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Главные авторы: Cha, Hyung Jin, Jang, Do Soo, Kim, Yeon-Gil, Hong, Bee Hak, Woo, Jae-Sung, Kim, Kyong-Tai, Choi, Kwan Yong
Формат: Artigo
Язык:Inglês
Опубликовано: Korea Society for Molecular and Cellular Biology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887930/
https://ncbi.nlm.nih.gov/pubmed/23740430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-013-0013-1
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