Structural double-mutant cycle analysis of a hydrogen bond network in ketosteroid isomerase from Pseudomonas putida biotype B

KSI (ketosteroid isomerase) catalyses an allylic isomerization reaction at a diffusion-controlled rate. A hydrogen bond network, Asp(99)···Water(504)···Tyr(14)···Tyr(55)···Tyr(30), connects two critical catalytic residues, Tyr(14) and Asp(99), with Tyr(30), Tyr(55) and a water molecule in the highly...

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Main Authors: Jang, Do Soo, Cha, Hyung Jin, Cha, Sun-Shin, Hong, Bee Hak, Ha, Nam-Chul, Lee, Ja Young, Oh, Byung-Ha, Lee, Heung-Soo, Choi, Kwan Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133972/
https://ncbi.nlm.nih.gov/pubmed/15228388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031871
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