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LIME Mediates Immunological Synapse Formation through Activation of VAV
Lck Interacting Membrane protein (LIME) was previously characterized as a transmembrane adaptor protein mediating TCR-dependent T cell activation. Here, we show that LIME associates with Vav in response to TCR stimulation and is required for Vav guanine nucleotide exchange factor (GEF) activity for...
में बचाया:
| मुख्य लेखकों: | , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Korea Society for Molecular and Cellular Biology
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887804/ https://ncbi.nlm.nih.gov/pubmed/22395814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-012-0011-8 |
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