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SOCS-6 Negatively Regulates T Cell Activation through Targeting p56(lck) to Proteasomal Degradation
The T cell-specific tyrosine kinase, p56(lck), plays crucial roles in T cell receptor (TCR)-mediated T cell activation. Here, we report that SOCS-6 (suppressor of cytokine signaling-6) is a negative regulator of p56(lck). SOCS-6 was identified as a protein binding to the kinase domain of p56(lck) th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844175/ https://ncbi.nlm.nih.gov/pubmed/20007709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073726 |
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