Genomic Analysis Identifies Targets of Convergent Positive Selection in Drug Resistant Mycobacterium tuberculosis

Mycobacterium tuberculosis is successfully evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including the genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly and 7 previously sequence...

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Hauptverfasser: Farhat, Maha R, Shapiro, B Jesse, Kieser, Karen J, Sultana, Razvan, Jacobson, Karen R, Victor, Thomas C, Warren, Robin M, Streicher, Elizabeth M, Calver, Alistair, Sloutsky, Alex, Kaur, Devinder, Posey, Jamie E, Plikaytis, Bonnie, Oggioni, Marco R, Gardy, Jennifer L, Johnston, James C, Rodrigues, Mabel, Tang, Patrick K C, Kato-Maeda, Midori, Borowsky, Mark L, Muddukrishna, Bhavana, Kreiswirth, Barry N, Kurepina, Natalia, Galagan, James, Gagneux, Sebastien, Birren, Bruce, Rubin, Eric J, Lander, Eric S, Sabeti, Pardis C, Murray, Megan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887553/
https://ncbi.nlm.nih.gov/pubmed/23995135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2747
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