Identification of a Developmental Gene Expression Signature, Including HOX Genes, for the Normal Human Colonic Crypt Stem Cell Niche: Overexpression of the Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis

Our goal was to identify a unique gene expression signature for human colonic stem cells (SCs). Accordingly, we determined the gene expression pattern for a known SC-enriched region—the crypt bottom. Colonic crypts and isolated crypt subsections (top, middle, and bottom) were purified from fresh, no...

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Autori principali: Bhatlekar, Seema, Addya, Sankar, Salunek, Moreh, Orr, Christopher R., Surrey, Saul, McKenzie, Steven, Fields, Jeremy Z., Boman, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2014
Soggetti:
Original Research Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887463/
https://ncbi.nlm.nih.gov/pubmed/23980595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0039
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