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Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex
LMO2 was discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for haematopoiesis. LMO2 is made up of two LIM only domains (thus it is a LIM-only protein) and forms a bridge in a multi-protein complex. We have studied the mechanism of formation of this comp...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887373/ https://ncbi.nlm.nih.gov/pubmed/24407558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03643 |
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