The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells.

The LIM-only protein LMO2 is expressed aberrantly in acute T-cell leukaemias as a result of the chromosomal translocations t(11;14) (p13;q11) or t(7;11) (q35;p13). In a transgenic model of tumorigenesis by Lmo2, T-cell acute leukaemias arise after an asymptomatic phase in which an accumulation of im...

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Bibliographic Details
Main Authors: Grütz, G G, Bucher, K, Lavenir, I, Larson, T, Larson, R, Rabbitts, T H
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170789/
https://ncbi.nlm.nih.gov/pubmed/9707419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.16.4594
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