Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

PCSK9 (proprotein convertase subtilisin/kexin type 9) is a negative regulator of the hepatic LDL receptor, and clinical studies with PCSK9-inhibiting antibodies have demonstrated strong LDL-c-lowering effects. Here we screened phage-displayed peptide libraries and identified the 13-amino acid linear...

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Autores principales: Zhang, Yingnan, Eigenbrot, Charles, Zhou, Lijuan, Shia, Steven, Li, Wei, Quan, Clifford, Tom, Jeffrey, Moran, Paul, Di Lello, Paola, Skelton, Nicholas J., Kong-Beltran, Monica, Peterson, Andrew, Kirchhofer, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887217/
https://ncbi.nlm.nih.gov/pubmed/24225950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514067
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