A Novel Family of Human Leukocyte Antigen Class II Receptors May Have Its Origin in Archaic Human Species

HLA class II α and β chains form receptors for antigen presentation to CD4(+) T cells. Numerous pairings of class II α and β subunits from the wide range of haplotypes and isotypes may form, but most of these combinations, in particular those produced by isotype mixing, yielded mismatched dimers. It...

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Bibliographic Details
Main Authors: Temme, Sebastian, Zacharias, Martin, Neumann, Jürgen, Wohlfromm, Sebastian, König, Angelika, Temme, Nadine, Springer, Sebastian, Trowsdale, John, Koch, Norbert
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887193/
https://ncbi.nlm.nih.gov/pubmed/24214983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515767
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