Antisense Oligonucleotide-stimulated Transcriptional Pausing Reveals RNA Exit Channel Specificity of RNA Polymerase and Mechanistic Contributions of NusA and RfaH

Transcript elongation by bacterial RNA polymerase (RNAP) is thought to be regulated at pause sites by open versus closed positions of the RNAP clamp domain, pause-suppressing regulators like NusG and RfaH that stabilize the closed-clamp RNAP conformation, and pause-enhancing regulators like NusA and...

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Bibliographic Details
Main Authors: Kolb, Kellie E., Hein, Pyae P., Landick, Robert
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887182/
https://ncbi.nlm.nih.gov/pubmed/24275665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521393
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