Colorectal Tumors from APC*I1307K Carriers Principally Harbor Somatic APC Mutations outside the A8 Tract

PURPOSE: APC*I1307K (c.3920T>A) is an inherited variant associated with colorectal tumour risk found almost exclusively in those of Ashkenazi Jewish ancestry. A single nucleotide substitution creates an oligo-adenine tract (A8) that appears to be inherently prone to further mis-pairing and slippa...

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Detalhes bibliográficos
Main Authors: Zauber, Peter, Bishop, Timothy, Taylor, Claire, Sabbath-Solitare, Marlene, Marotta, Stephen, Tomlinson, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886998/
https://ncbi.nlm.nih.gov/pubmed/24416237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084498
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