Rad GTPase Deletion Increases L‐type Calcium Channel Current Leading to Increased Cardiac Contraction

BACKGROUND: The small GTPase Rad is a negative regulator of voltage‐dependent L‐type calcium channel current (I(C)(aL)); however, the effects of Rad ablation on cardiomyocyte function are unknown. The objective of this study is to test the hypothesis that Rad‐depletion causes positive inotropic effe...

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Bibliographic Details
Main Authors: Manning, Janet R., Yin, Guo, Kaminski, Catherine N., Magyar, Janos, Feng, Han‐Zhong, Penn, John, Sievert, Gail, Thompson, Katherine, Jin, J.‐P., Andres, Douglas A., Satin, Jonathan
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886777/
https://ncbi.nlm.nih.gov/pubmed/24334906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000459
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