Mechanism of Inhibition of Bacillus subtilis DNA Polymerase III by the Arylhydrazinopyrimidine Antimicrobial Agents

Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5′-mononucleotides....

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Low, Robert L., Rashbaum, Stephan A., Cozzarelli, Nicholas R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1974
Schlagworte:	Biological Sciences: Biochemistry
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388601/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4213240/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.8.2973
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