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The antimalarial drug quinine interferes with serotonin biosynthesis and action

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As tryptophan is a precursor of the neurotransmitter...

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Main Authors: Islahudin, Farida, Tindall, Sarah M., Mellor, Ian R., Swift, Karen, Christensen, Hans E. M., Fone, Kevin C. F., Pleass, Richard J., Ting, Kang-Nee, Avery, Simon V.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885885/
https://ncbi.nlm.nih.gov/pubmed/24402577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03618
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