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The Antimalarial Drug Quinine Disrupts Tat2p-mediated Tryptophan Transport and Causes Tryptophan Starvation

Quinine is a major drug of choice for the treatment of malaria. However, the primary mode of quinine action is unclear, and its efficacy is marred by adverse reactions among patients. To help address these issues, a genome-wide screen for quinine sensitivity was carried out using the yeast deletion...

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Bibliografiska uppgifter
Huvudupphovsmän: Khozoie, Combiz, Pleass, Richard J., Avery, Simon V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709357/
https://ncbi.nlm.nih.gov/pubmed/19416971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005843
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