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The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the Medicines for Malaria Venture (MMV) Malaria Box of candidate anti...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Vallières, Cindy, Avery, Simon V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571370/
https://ncbi.nlm.nih.gov/pubmed/28652237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00459-17
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