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Targeting an Achilles’ heel of cancer with a WRN helicase inhibitor

Our recently published work suggests that DNA helicases such as the Werner syndrome helicase (WRN) represent a novel class of proteins to target for anticancer therapy. Specifically, pharmacological inhibition of WRN helicase activity in human cells defective in the Fanconi anemia (FA) pathway of in...

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Sonraí Bibleagrafaíochta
Main Authors: Aggarwal, Monika, Banerjee, Taraswi, Sommers, Joshua A, Brosh, Jr, Robert M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885643/
https://ncbi.nlm.nih.gov/pubmed/24036544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26320
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