GITR Pathway Activation Abrogates Tumor Immune Suppression Through Loss of Regulatory T cell Lineage Stability

Ligation of GITR (glucocorticoid-induced tumor necrosis factor (TNF) receptor-related gene, or TNFRSF18) by agonist antibody has recently entered into early phase clinical trials for the treatment of advanced malignancies. Although the ability of GITR modulation to induce tumor regression is well-do...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Schaer, David A., Budhu, Sadna, Liu, Cailian, Bryson, Campbell, Malandro, Nicole, Cohen, Adam, Zhong, Hong, Yang, Xia, Houghton, Alan N., Merghoub, Taha, Wolchok, Jedd D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885345/
https://ncbi.nlm.nih.gov/pubmed/24416730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0086
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