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Differential roles for the Co(2+)/Ni(2+) transporting ATPases, CtpD and CtpJ, in Mycobacterium tuberculosis virulence

The genome of Mycobacterium tuberculosis encodes two paralogous P(1B4)-ATPases, CtpD (Rv1469) and CtpJ (Rv3743). Both proteins showed ATPase activation by Co(2+) and Ni(2+), and both appear to be required for metal efflux from the cell. However, using a combination of biochemical and genetic studies...

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Detalhes bibliográficos
Main Authors: Raimunda, Daniel, Long, Jarukit E., Padilla-Benavides, Teresita, Sassetti, Christopher M., Argüello, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885230/
https://ncbi.nlm.nih.gov/pubmed/24255990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12454
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