A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells.

Germ-line missense mutations of the receptor-like tyrosine kinase ret are the causative genetic event of the multiple endocrine neoplasia (MEN) type 2A and type 2B syndromes and of the familial medullary thyroid carcinoma. We have used the rat pheochromocytoma cell line, PC12, as a model system to i...

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Main Authors: Califano, D, D'Alessio, A, Colucci-D'Amato, G L, De Vita, G, Monaco, C, Santelli, G, Di Fiore, P P, Vecchio, G, Fusco, A, Santoro, M, de Franciscis, V
Formato: Artigo
Idioma:Inglês
Publicado: 1996
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC38852/
https://ncbi.nlm.nih.gov/pubmed/8755580
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