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Vanadium-catalyzed oxidative Strecker reaction: α-C–H cyanation of para-methoxyphenyl (PMP)-protected primary amines

We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method...

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Detalhes bibliográficos
Main Authors: Zhu, Chen, Xia, Ji-Bao, Chen, Chuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885172/
https://ncbi.nlm.nih.gov/pubmed/24415804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.11.012
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