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Rational design of microRNA–siRNA chimeras for multifunctional target suppression
MicroRNAs (miRNAs) are involved in a variety of human diseases by simultaneously suppressing many gene targets. Thus, the therapeutic value of miRNAs has been intensely studied. However, there are potential limitations with miRNA-based therapeutics such as a relatively moderate impact on gene target...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3884671/ https://ncbi.nlm.nih.gov/pubmed/24145823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.039677.113 |
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